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| R4 | Jonathan Holtzman d. David Buchinsky | 6-4; 6-3 |
| R4 | Sean Patrick d. Jackson Allen | 6-4; 6-2 |
| R4 | Jake Bhangdia d. Charlie Adkins | 7-5; 6-2 |
| R4 | Doug Francken d. Brian Niguidula | 6-2; 6-1 |
| R4 | Kaleb Dobbs d. Christian Gloria | 4-6; 7-5; 6-2 |
| R4 | Ananth Raghavan d. Jake Kuhlman | 6-1; 6-3 |
| R4 | Richard Ciamarra d. Daniel Mateescu | 6-3; 7-5 |
| R4 | Jordan Benjamin d. Nicholas Beaty | 6-3; 6-3 |
| R4 | Athell Bennett d. Vidyut Yadav | 6-0; 6-0 |
| R4 | Connor Johnston d. Matthew Jacobs | 6-2; 6-2 |
| R4 | Robin Engel d. Justin Lee | 6-1; 6-0 |
| R4 | Harris Foulkes d. Craig Campbell | 6-2; 7-6; 6-2; 6-2 |
| R4 | Franklin Brozovich d. Travis Leaf | 2-6; 6-3; 7-6(7) |
| R4 | Davis Wong d. Alex Chao | 6-3; 6-4 |
| R4 | Rj Fresen d. Luke Moorhead | 6-4; 6-4 |
| R4 | William Andrews d. Bill Duo | 6-1; 4-67-6(5) |
| R4 | Ryan Fu d. Eric Wing | 6-2; 6-0 |
| R4 | Cole Gittens d. Addison Cazier | 6-3; 6-2 |
| R4 | Aleksandar Kovacevic d. Anthony Rosa | 6-4; 6-4 |
| R4 | Colin Sacco d. Dj Colantone | 6-0; 6-0 |
| R4 | John Speicher d. Jason Howard | 6-0; 6-1 |
| R4 | Sean Mullins d. Jack Geissler | 3-6; 7-6(3); 6-3 |
| R4 | Alan Dubrovsky d. Henry Hedeman | 6-1; 7-6(5) |
| R4 | Robert Smithline d. Jack Collison | 6-2; 6-1 |
| R4 | John Drake d. Tj Oosterbaan | 6-0; 6-1 |
| R4 | David Horneffer d. Peter Conklin | 3-6; 6-1; 6-4 |
| R4 | Aanik Lohani d. Jeffrey Zucker | 1-6; 1-1 Ret (inj) |
| R4 | Nick Kallman d. Aaron Pezzullo | 6-3; 6-3 |
| R4 | Chuck Tang d. Nicholas Fauchet | 7-5; 6-3 |
| R4 | Alex Knaff d. Josh Mukherjee | 6-3; 7-5 |
| R4 | Jordan Jordan d. Rajeev Laungani | 6-2; 2-6; 7-6(4) |
| R4 | Nathan Kaplan d. Nicholas Calzolano | 6-2; 6-1 |
| R4 | Michael Czlonka d. Camden Mazzoni | 6-4; 6-3 |
| R4 | Chris Kuhnle d. Mark Johnson | 6-4; 6-0 |
| R4 | Earl Hsieh d. Austin Wong | 6-4; 6-2 |
| R4 | Revanth Boppana d. Christopher Adams | 6-3; 5-7; 6-2 |
All Boys' 14 Singles Matches
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| R4 | Alexandra Koniaev d. Zoe Klass-Warch | 6-1; 6-3 |
| R4 | Sophia Haleas d. Isis Gill | 6-2; 4-6; 6-1 |
| R4 | Madeline Dewire d. Danielle Burich | 6-2; 6-3 |
| R4 | Cecelia Lesnick d. Alexia Meyer | 6-4; 2-6; 6-3 |
| R4 | Grace Joyce d. Caroline McAuley | 6-3; 6-0 |
| R4 | Sasha Hartje d. Lindsey Evans | 6-0; 6-0 |
| R4 | Leigh Friedman d. Jennifer Richards | 3-6; 6-3; 6-1 |
| R4 | Loren Haukova d. Kylie Boyer | 6-1; 6-2 |
| R4 | Elysia Bolton d. Regina Furer | 6-2; 6-2 |
| R4 | Samantha Czarnecki d. Courtney Ollis | 7-6(4); 6-3 |
| R4 | Ashley Granieri d. Taylor Jackson | 6-2; 6-4 |
| R4 | Ekim Buyuk d. Lise Swain | 7-6(6); 2-6; 6-2 |
| R4 | Hannah Berg d. Jordan Kopfer | 6-1; 6-0 |
| R4 | Courtney Provan d. Alyvia Jones | 6-3; 6-3 |
| R4 | Alexandra DeNucci d. Maeve Koscielski | 6-2; 6-1 |
| R4 | Claire Handa d. Andjelija Bozovic | 4-6; 6-3; 7-6(1) |
| R4 | Alexandra Sabe d. Hayley Haakenstad | 6-2; 6-1 |
| R4 | Alexus Gill d. Chloe Hall | 2-6; 6-0; 6-2 |
| R4 | Celeste Matute d. Elizabeth Bauss | 6-3; 6-3 |
| R4 | Claire Reifeis d. Mary Ann Rompf | 6-2; 6-3 |
| R4 | Victoria Sec d. Isabella Lambert | 6-3; 6-2 |
| R4 | Ashley Avery d. Paige Cooley | 6-1; 6-1 |
| R4 | Chiara Lommer d. Allison McCann | 6-3; 4-6; 7-5 |
| R4 | Sophia Haleas d. Isis Gill | 6-2; 4-61 |
| R4 | Christina Sisti d. Haley Lickfold | 6-2; 6-1 |
| R4 | Libby Rickeman d. Brianna Gibbs | 6-2; 6-1 |
| R4 | Yuka Lin d. Caroline Szabo | 7-5; 4-6; 6-2 |
| R4 | Tamara Comins d. Mccoy Hutchison | 6-3; 6-3 |
| R4 | Sasa Jovanovic d. Emily Luetschwager | 6-4; 6-3 |
| R4 | Angelina Ye d. Kateri Martin | 3-6; 6-3; 6-2 |
| R4 | Stephanie Simon d. Allyson Persky | 7-6(5); 6-2 |
| R4 | Stephanie Schrage d. Alexandra Abele | 3-6; 6-2; 6-1 |
| R4 | Sophia He d. Lindsey Tibbles | 6-0; 6-2 |
| R4 | Ada Wiggins d. Megan Guenther | 6-0; 6-2 |
| R4 | Courtney Kowalsky d. Mira Amin | 6-1; 6-0 |
| R4 | Brianna Williams d. Natalie Lorentz | 6-1; 6-0 |
| R4 | Scarlett Blydenburgh d. Taylor Sprouse | 6-1; 6-1 |
All Girls' 14 Singles Matches
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