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| R4 | Jarod Hing d. Chase Bernstine | 6-1 Ret (inj) |
| R4 | Alejandro Rodriguez-Vidal d. Sage Leaman | 6-1 Ret (inj) |
| R4 | Kabir Sarita d. Dylan Levitt | 6-3; 6-3 |
| R4 | Casey Ross d. Luke Ross | 6-2; 6-0 |
| R4 | Vishnu Joshi d. Chase Stoner | 7-6; 6-2 |
| R4 | Michael Dickson d. Ryland McDermott | 7-5; 6-1 |
| R4 | Adam Guo d. John Carlin | Wd (ill) |
| R4 | Austen Huang d. Johnathan Small | 7-6; 6-3 |
| R4 | Alexander Exsted d. Stratton Brown | 6-3; 5-7; 1-0(5) |
| R4 | Jorge Ortiz d. Brent Bersola | 7-5; 6-2 |
| R4 | Jonathan Sheehy d. William Peters | 3-6; 6-0; 6-4 |
| R4 | Robert Maciag d. Malachi Coleman | 6-2; 6-4 |
| R4 | Tripp Tuff d. Colton Weeldreyer | 6-2; 6-2 |
| R4 | Sean Burnette d. Jack Katzman | 3-0 Ret (inj) |
| R4 | Phuc Huynh d. Shandor Gomez | 6-2; 6-1 |
| R4 | Jack Tascher d. Ethan Prost | 6-4; 6-2 |
| R4 | Nikita Snezhko d. Sriram Sugumaran | 6-3; 6-4 |
| R4 | Kaleb Dobbs d. Tyler Raclin | 6-4; 7-5 |
| R4 | Christian Alshon d. Jackson Suh | 6-3; 6-3 |
| R4 | Joey Short d. Rayden Murata | 6-2; 6-2 |
| R4 | Trey Hilderbrand d. Peter Conklin | 6-4; 7-6 |
| R4 | Jourdan Kast d. Ty Gentry | 6-2; 6-4 |
| R4 | Ignacio Garcia d. Jace Akagi-Okuma | 6-1; 6-2 |
| R4 | Maxwell Freeman d. Erik Kerrigan | 7-6; 4-6; 6-2 |
| R4 | David Horneffer d. Alexander Keyser | 6-0; 6-3 |
| R4 | Yash Parikh d. Jacob Walker | 6-3; 6-1 |
| R4 | Alex Phillips d. Timothy Sah | 6-3; 6-4 |
| R4 | Aleksandar Kovacevic d. Jason Lui | 6-3; 6-4 |
| R4 | Jacob Brumm d. Sean Sculley | 7-5; 6-3 |
| R4 | Brady Draheim d. Nicholas Beaty | 6-2; 6-4 |
| R4 | Keegan Smith d. Nick Stachowiak | 6-4; 6-3 |
| R4 | Richard Ciamarra d. Chase Wood | 5-7; 6-1; 6-2 |
| R4 | Bennett Crane d. Connor Hance | 6-4; 6-1 |
| R4 | Joseph Thomas d. Amit Batta | 6-1; 5-7; 7-5 |
| R4 | Ryan Kros d. Christopher Steele | 6-3; 2-1 Ret (inj) |
| R4 | Connor Johnston d. Paul Barretto | 6-4; 4-6; 6-1 |
| R4 | Jackson Allen d. Alexander Brown | 6-4; 7-5 |
| R4 | Ethan Hillis d. Alex Mascioli | 6-1; 6-1 |
| R4 | Brandon Stringfellow d. Conor Somers | 2-6; 7-6; 1-0(8) |
| R4 | Ryan Seggerman d. Aleks Huryn | 7-6; 3-6; 6-2 |
| R4 | Guillermo Lopez Torres d. Seann Esaki | 6-3; 6-0 |
| R4 | Payton Holden d. Matthew Lord | 6-1; 3-6; 6-2 |
| R4 | Steven Forman d. Randy Cory | 7-5; 6-0 |
| R4 | Michael Zhao d. Benjamin Gajardo | 2-6; 6-3; 6-0 |
| R4 | Bill Duo d. Andre Xiao | 6-3; 6-1 |
| R4 | Joseph McAllister d. Charlie Adkins | 6-0; 6-1 |
| R4 | Billy Rowe d. Galen Lee | 6-3; 6-0 |
All Boys' 18 Singles Matches
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